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Your Acura MDX has a 5 speaker system which are all retrained when installing this aftermarket radio. If you have BOSE or don’t have BOSE you will keep all your speakers including the subwoofer and your factory amplifier. Your factory navigation touchscreen will continue to function but there will be no audio so you will lose route guidance and other prompts. The backup camera will continue to work through the factory screen. If you don’t have a touchscreen the trip screen will work as normal. You will also get to keep your steering wheel control buttons including volume up, volume down, next, previous and mode. Call control buttons are not retained. You will lose the factory Bluetooth functionality and use the Bluetooth from the new aftermarket radio instead. If you upgrade your radio you will lose rear entertainment, external CD changer, external DVD player, factory Sirius XM and OnStar.